ABOUT US

课题组简介

闫致强，首都医科大学基础医学院教授、院长，首都医学科学创新中心医学生理学研究所资深研究员、所长。2004年获复旦大学学士学位， 2004-2009年分别于中国科学院神经科学研究所、北京生命科学研究所以及中科院生物物理研究所进行博士研究并获得博士学位。2009-2013加州大学旧金山分校及霍华德•休斯医学研究所师从著美国科学院院士詹裕农，叶公杼 (Yuh-Nung Jan，Lily Jan)进行博士后研究。2013-2020年任复旦大学生命科学学院研究员、 博士生导师，2020-2024年任深圳湾实验室分子生理所资深研究员、副所长。长期致力于感觉神经生物学，尤其是听觉、触觉、渴觉等感觉受体的鉴定和门控机理研究，感觉系统神经回路，以及感觉系统疾病的机理和治疗。以通讯作者在Neuron、PNAS、Nature Structural & Molecular Biology、Nature Communications 和Cell Reports 等国际高水平杂志发表多篇论文。

Dr. Zhiqiang Yan is a professor and dean of the School of Basic Medical Sciences at Capital Medical University, as well as an investigator and director at the Institute for Medical Physiology, Chinese Institutes for Medical Research, Beijing. He earned his bachelor's degree from Fudan University in 2004 and completed his Ph.D. in neurobiology at the Institute of Neuroscience, Chinese Academy of Sciences, the National Institute of Biological Sciences, Beijing, and the Institute of Biophysics, Chinese Academy of Sciences, from 2004 to 2009. Following his Ph.D., Dr. Yan conducted his postdoctoral research under the mentorship of Academicians Yuh-Nung Jan and Lily Jan at the Howard Hughes Medical Institute and the University of California, San Francisco. In 2013, he became a professor at the School of Life Sciences, Fudan University. From 2020 to 2024, he served as a senior principal investigator and deputy director at the Institute of Molecular Physiology, Shenzhen Bay Laboratory. Dr. Yan studies sensory neurobiology, focuses on identifying the receptors and neural circuits for sensation and interoception, studies their working mechanism and related the diseases in sensory system. He has published numerous papers as a corresponding author in high-impact journals, including Neuron, PNAS, Nature Structural & Molecular Biology, Nature Communications, and Cell Reports.

课题组研究方向

闫致强实验室长期从事感觉神经生物学的研究，综合运用分子生物学、蛋白相互作用和结构分析、电生理记录、神经回路的光遗传、化学遗传和成像等技术手段，结合药物筛选和基因编辑小鼠模型，进行听觉、触觉、渴觉等感觉受体的鉴定和工作机制研究，感觉系统神经回路，以及感觉系统疾病的机理和治疗，并探索这些感觉受体在其他重要生理功能中的作用。

• 听觉、触觉、痛觉、湿度感觉、渴觉等感觉受体的鉴定，其装配和工作机制研究，以及这些受体在其他重要生理过程中的作用，例如消化和免疫反应。
• 解析感觉受体离子通道及其复合物的蛋白结构、分析离子通透性和门控机制等。
• 鉴定在触觉、痛觉、平衡觉、听觉、渴觉、内脏感觉等的关键神经细胞群和神经回路。
• 研究遗传性耳聋的致病机理、诊断以及基因治疗。

Research direction：

We study sensory neurobiology, focusing on identifying the receptors and neural circuits for sensation and interoception, studying their working mechanism, and relating the diseases in the sensory system.

• Identify the receptors for hearing, touch, pain, and thirst sensation, study the gating and assembly of the related sensory transduction complex, and explore their functions in various physiological processes, such as digestion and immunity.
• Analysis of the protein structures of sensory receptor ion channels and their complexes, as well as the examination of ion permeability and gating mechanisms.
• Map the critical neuronal groups and circuits for sensation and interoception, such as touch, pain, vestibular, and thirst sensation.
• Study the pathogenic mechanism, diagnosis, and treatment of congenital hearing loss.

招聘专业背景

因课题组科研工作需要，诚招神经生物学、分子生物学与生物化学、生理学、细胞生物学、结构生物学、药物化学等生物医学研究相关专业背景的人员，实验室十分欢迎多学科专业融合发展。

We are looking for aspiring young people with professional backgrounds in neurobiology, molecular biology and biochemistry, cell biology, structural biology, pharmaceutical chemistry, etc. are sincerely invited. The laboratory welcomes the integration and development of multi-disciplinary specialties.

招聘岗位介绍

福利待遇

• 根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；
• 提供良好的科研工作环境，尖端的技术支撑平台；
• 协助申请国家级、地方级人才项目和人才奖励；
• 支持个人职业发展，提供必要的工作相关专业培训；
• 享受五险一金、带薪年假、体检和补充医疗保险等。

Qualified candidates will receive an internationally competitive salary, state-of-the-art core facilities. Assistance will be provided in applying for national and regional talent awards and subsidies. Supporting personal career development and providing necessary job-related professional training. Other benefits include Social insurance, paid annual leave, physical examination, and supplementary medical insurance, etc.

应聘方法

应聘者请提供以下 PDF 版材料：

• 个人简历及代表性科研成果；
• 科研兴趣或计划；
• 其它能够证明科研能力的材料。

（1）Curriculum vitae, including lists of publications and research funding;（2）Research interest or plan;（3）Other materials that can prove scientific research ability.

请应聘者将上述材料，统一成 PDF 文件发送至：yan_lab@cimrbj.ac.cn（邮件主题：应聘者姓名 + 应聘职位）。